|
T6854 |
GSK621
|
|
Apoptosis
,
AMPK
,
Autophagy
|
|
GSK621 is a specific and potent AMPK activator. |
|
T0159 |
Pranoprofen
|
Pyranoprofen |
Apoptosis
,
COX
,
PGE Synthase
,
Prostaglandin Receptor
|
|
Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology. |
|
T1862 |
PR-619
|
PR 619,2,6-Diamino-3,5-dithiocyanopyridine |
Apoptosis
,
DUB
,
Autophagy
|
|
PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs). |
|
T13867 |
RH01386
|
|
Others
|
|
RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired ... |
|
T6993 |
Tauroursodeoxycholate sodium
|
Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,Sodium Tauroursodeoxycholate (TUDC) |
Apoptosis
,
ERK
,
Caspase
|
|
Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis. |
|
T20797 |
NE-100 hydrochloride
|
NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl |
Sigma receptor
|
|
NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death. |
|
T29017 |
TrxR1-IN-B19
|
TrxR1INB19,Go Y015,TrxR1 IN B19,Go-Y015 |
Others
|
|
TrxR1-IN-B19 (TrxR1 IN B19), a TrxR1 inhibitor, selectively kills gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation. |
|
T13219 |
TTA-Q6
|
|
Calcium Channel
|
|
TTA-Q6 is a selective T-type Ca2+ channel antagonist with potential antitumor and immunomodulatory activity for the treatment of neurological disorders by inhibiting the uptake of extracellular calcium ions by tumor cell... |
|
T8982 |
RH01687
|
|
Others
|
|
RH01687 is a potent β-cell protector , exhibits β-cell-protective activities against endoplasmic reticulum (ER) stress. |
|
T9110 |
Ceapin-A7
|
|
Others
|
|
Ceapin-A7, with an IC50 of 0.59 μM, selectively inhibits ATF6α signaling in response to ER stress. This compound is instrumental in investigating ATF6α's activation mechanism and its function in pathological conditions. |
|
T40130 |
Nur77 modulator 1
|
Nur77 modulator 1 |
Others
|
|
Nur77 modulator 1 is a good Nur77 binder (KD = 3.58 μM). Nur77 modulator 1 up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell ... |
|
T24855 |
TASIN-1 Hydrochloride
|
TASIN-1 HCl,TASIN 1 HCl,TASIN1 HCl |
APC
|
|
TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apopt... |
|
T8901 |
YUM70
|
|
Apoptosis
,
GPR
,
HSP
|
|
YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediate... |
|
T9564 |
IRE1α kinase-IN-1
|
|
IRE1
|
|
IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosph... |
|
T12009 |
Telomerase-IN-1
|
|
Telomerase
|
|
Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 μM). telomerase-IN-1 activates hTERT expression through the endoplasmic reticulum stress (ERS) of the ER overreaction (EOR), which then induces ERS, leading to apopto... |
|
T26973 |
Cefatrizine
|
Cephatriazine,BL-S-640,BLS640,S 640P,BL S 640 |
|
|
Cefatrizine is an inhibitor of eukaryotic elongation factor-2 kinase, a unique calcium/calmodulin-dependent protein kinase, is well known to regulate apoptosis, autophagy and ER stress in many types of human cancers. |
|
T36328 |
Termitomycamide B
|
|
|
|
Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson's, Alzheimer's, and prion disease... |
|
T72543 |
BOLD-100 free base
|
NKP-1339 free base ; IT-139 free base ; KP-1339 free base,KP-1339 free base,NKP-1339 free base,IT-139 free base |
|
|
BOLD-100 free base (NKP-1339; IT-139), a ruthenium-based anticancer agent, inhibits stress-induced GRP78 upregulation, thus disrupting endoplasmic reticulum (ER) homeostasis. This action induces ER stress and unfolded pr... |
|
T27736 |
KM10103
|
KM-10103,KM 10103 |
|
|
KM10103 exhibits β-cell-protective activities against ER stress, which plays an important role in the decline in pancreatic β cell function and mass observed in type 2 diabetes. |
|
T73096 |
Z-LEVD-FMK
|
|
|
|
Z-LEVD-FMK, a cell-permeable caspase-4 inhibitor, effectively blocks endoplasmic reticulum (ER) stress-induced apoptosis in cancer cells. |
|
T71151 |
Z36
|
|
|
|
Z36 is a novel Bcl-xL inhibitor, upregulating the expression levels of FAM134B, LC3, and Atg9, inducing autophagy along with autophagic cell death, resulting in ER stress and the unfolded protein response (UPR). |
|
T75738 |
Microcystin-RR
|
|
|
|
Microcystin-RR (Cyanoviridin RR), a potent orally active inhibitor of protein phosphatase, induces apoptosis and endoplasmic reticulum (ER) stress in mouse liver [1] [2]. |
|
T78528 |
ERX-41
|
|
Others
|
|
ERX-41 is an orally active, stereospecific small molecule that targets lysosomal acid lipase A (LIPA). It induces endoplasmic reticulum (ER) stress, leading to cell death independently of its LIPA activity yet reliant on... |
|
T79013 |
SLMP53-2
|
|
|
|
SLMP53-2 is a mutant p53 reactivator that restores the wild-type-like conformation and DNA-binding ability of mutp53-Y220C through enhanced interaction with Hsp70, thereby reinstating p53's transcriptional activity. This... |
|
T79359 |
Anticancer agent 147
|
|
Ferroptosis
|
|
Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA), enhances endoplasmic reticulum ... |
|
T76254L |
CD31 TFA
|
|
|
|
CD31 TFA, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), functions as the specific receptor for Clostridium perfringens beta-Toxin (CPB) in endothelial cells. It is recognized as an ER-MP12 antige... |
|
T76254 |
CD31
|
|
|
|
CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a receptor on endothelial cells for clostridium perfringens beta-Toxin (CPB). It also functions as an ER-MP12 antigen and connects mechanica... |
|
T78007 |
Vasonatrin Peptide (VNP) TFA
|
|
|
|
Vasonatrin Peptide (VNP) TFA, a chimeric compound derived from atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP), exhibits venodilating properties reminiscent of CNP, natriuretic effects akin to ANP, ... |
|
T36610 |
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine
|
|
|
|
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP r... |
|
T36570 |
KUS121
|
|
|
|
KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, ... |
|
T83857 |
Soluble Epoxide Hydrolase PROTAC 1a
|
sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a |
|
|
Soluble epoxide hydrolase (sEH) PROTAC 1a is a proteolysis-targeting chimera (PROTAC) comprising a cereblon ligand linked to the sEH inhibitor t-TUCB via a linker, promoting selective sEH degradation and inhibiting its h... |
